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Copyright Korean Society of Pathologists, Korean Society for Cytopathology Oct 2013

Abstract

Hepatocellular adenoma (HCA) is a rare benign tumor of the liver. A subtype classification of HCA (hepatocyte nuclear factor 1? [HNF1?]-mutated, β-catenin-mutated HCA, inflammatory HCA, and unclassified HCA) has recently been established based on a single institutional review of a HCA series by the Bordeaux group. We used histologic and immunohisto-chemical parameters to classify and evaluate eight cases from our institution. We evaluated the new classification method and analyzed correlations between our results and those of other reports. Seven of our eight cases showed histologic and immunohistochemical results consistent with previous reports. However, one case showed overlapping histologic features, as previously described by the Bordeaux group. Four cases showed glutamine synthetase immuno- histochemical staining inconsistent with their classification, indicating that glutamine synthetase staining may not be diagnostic for β-catenin-mutated HCA. HNF1?-mutated HCA may be indicated by the absence of liver fatty acid binding protein expression. Detection of amyloid A may indicate inflammatory HCA. HCA with no mutation in the HNF1? or β-catenin genes and no inflammatory protein expression is categorized as unclassified HCA. Although the new classification is now generally accepted, validation through follow-up studies is necessary. [PUBLICATION ABSTRACT]

Details

Title
Clinicopathological Analysis of Hepatocellular Adenoma According to New Bordeaux Classification: Report of Eight Korean Cases
Author
Kim, Hyunchul; Jang, Ja-June; Kim, Dong-Sik; Yeom, Beom Woo; Won, Nam Hee
Pages
411-417
Section
ORIGINAL ARTICLE
Publication year
2013
Publication date
Oct 2013
Publisher
Korean Society of Pathologists, Korean Society for Cytopathology
ISSN
17381843
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1460233149
Copyright
Copyright Korean Society of Pathologists, Korean Society for Cytopathology Oct 2013