Abstract

Doc number: 12

Abstract

Background: Shivering is a very common complication in the postanesthesia period. Increasing studies have reported ondansetron may be effective in prevention of postanesthesia shivering (PAS). However, the results remained controversial; hence we conducted a meta-analysis of randomized controlled trials to evaluate the efficacy and safety of ondansetron on the prevention of postanesthesia shivering.

Methods: PubMed and Embase databases were searched to identify the eligible randomized controlled trials assessing the effect of ondansetron on the prevention of PAS. Results were expressed as risk ratios (RRs) with accompanying 95% confidence intervals (CIs). The meta-analysis was performed with fixed-effect model or random-effect model according to the heterogeneity.

Results: Six trials including 533 subjects were included. Compared with placebo, ondansetron was associated with a significant reduction of PAS (RR 0.43, 95% CI, 0.27-0.70), without an increased risk of bradycardia (RR 0.37, 95% CI, 0.12-1.15). Compared with meperidine, no difference was observed in the incidence of PAS (RR 0.68, 95% CI, 0.39-1.19) and bradycardia (RR 2.0, 95% CI, 0.38-10.64).

Conclusions: Ondansetron has a preventive effect on PAS without a paralleled side effect of bradycardia.

Details

Title
Efficacy and safety of ondansetron in preventing postanesthesia shivering: a meta-analysis of randomized controlled trials
Author
Tie, Hong-Tao; Su, Guang-Zhu; He, Kun; Liang, Shao-Rong; Yuan, Hao-Wei; Mou, Jun-Huan
Publication year
2014
Publication date
2014
Publisher
BioMed Central
e-ISSN
14712253
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1505023560
Copyright
© 2014 Tie et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.