Full text

Turn on search term navigation

Copyright © 2014 Hai Wang et al. Hai Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

It still remains a major challenge to repair large bone defects in the orthopaedic surgery. In previous studies, a nanohydroxyapatite/collagen/poly(L-lactic acid) (nHAC/PLA) composite, similar to natural bone in both composition and structure, has been prepared. It could repair small sized bone defects, but they were restricted to repair a large defect due to the lack of oxygen and nutrition supply for cell survival without vascularization. The aim of the present study was to investigate whether nHAC/PLA composites could be vascularized in vivo. Composites were implanted intramuscularly in the groins of rabbits for 2, 6, or 10 weeks ( n = 5 × 3 ). After removing, the macroscopic results showed that there were lots of rich blood supply tissues embracing the composites, and the volumes of tissue were increasing as time goes on. In microscopic views, blood vessels and vascular sprouts could be observed, and microvessel density (MVD) of the composites trended to increase over time. It suggested that nHAC/PLA composites could be well vascularized by implanting in vivo. In the future, it would be possible to generate vascular pedicle bone substitutes with nHAC/PLA composites for grafting.

Details

Title
Vascularization of Nanohydroxyapatite/Collagen/Poly(L-lactic acid) Composites by Implanting Intramuscularly In Vivo
Author
Wang, Hai; Chang, Xiao; Qiu, Guixing; Cui, Fuzhai; Weng, Xisheng; Zhang, Baozhong; Lian, Xiaojie; Wu, Zhihong
Publication year
2014
Publication date
2014
Publisher
John Wiley & Sons, Inc.
ISSN
16879422
e-ISSN
16879430
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1512875384
Copyright
Copyright © 2014 Hai Wang et al. Hai Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.