Abstract

Doc number: 88

Abstract

Background: Pathogenesis of gallstones (GS) is multifactorial and multiple genetic and environmental factors have been identified in different populations for different types of GS with varying prevalence. However the role of the each aetiological factor on the formation of mixed cholesterol and black pigment GS has not being addressed adequately. Hence in this study we attempted to compare known possible risk factors for mixed cholesterol and black pigment GS among two groups of patients with two types of GS.

Methods: The study was done on a cohort of patients with symptomatic GS admitted to the Teaching Hospital Peradeniya, Sri Lanka over a period of 18 months. Clinical and epidemiological data and physical parameters of the patients were recorded and surgically removed GS were analyzed chemically and physically to identify the type of GS. In addition lipid profile was done in all the patients with normal serum bilirubin levels.

Results: A total of 86 patients were included in the study. Mixed cholesterol GS was significantly common among females than males (χ2 test, p = 0.029). Mixed cholesterol GS was commonly seen among patients belonging to Moor ethnicity (χ2 test, p = 0.009). Majority of patients with mixed cholesterol GS had body mass index above 25 kg/m2 (χ2 test, p = 0.018). Black pigment GS were significantly common among patients with type II diabetes mellitus (Fisher's exact test, p = 0.035). Further all the patients with chronic haemolytic anaemia and alcoholic cirrhosis had black pigment GS. Age, family history, Fasting Blood Glucose, dyslipidaemia, lipid profile, parity and use of oral contraceptive pills in females, smoking and alcohol intake in males did not differ significantly among patients in the two groups.

Conclusion: Gender, ethnicity and body mass index can be used to predict the formation of mixed cholesterol GS and black pigment GS.

Details

Title
Can the type of gallstones be predicted with known possible risk factors?: a comparison between mixed cholesterol and black pigment stones
Author
Weerakoon, Harshi TW; Ranasinghe, Jamburagoda GS; Navaratna, Ayanthi; Sivakanesan, Ramaiah; Galketiya, Kuda B; Rosairo, Shanthini
Pages
88
Publication year
2014
Publication date
2014
Publisher
BioMed Central
e-ISSN
1471230X
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1471-230X-14-88
ProQuest document ID
1524007588
Copyright
© 2014 Weerakoon et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.