Abstract

The benefits of increased safety and cost-effectiveness make vegetable crops appropriate systems for the production and delivery of pharmaceutical proteins. In particular, Solanaceae edible crops could be inexpensive biofactories for oral vaccines and other pharmaceutical proteins that can be ingested as minimally processed extracts or as partially purified products. The field of crop plant biotechnology is advancing rapidly due to novel developments in genetic and genomic tools being made available today for the scientific community. In this review, we briefly summarize data now available regarding genomic resources for the Solanaceae family. In addition, we describe novel strategies developed for the expression of foreign proteins in vegetable crops and the utilization of these techniques to manufacture pharmaceutical proteins.

Details

Title
Production of Pharmaceutical Proteins in Solanaceae Food Crops
Author
Rigano, Maria Manuela; Guzman, Giorgio De; Walmsley, Amanda M; Frusciante, Luigi; Barone, Amalia
Pages
2753-2773
Publication year
2013
Publication date
2013
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1526025593
Copyright
Copyright MDPI AG 2013