Abstract

Doc number: 109

Abstract

Purpose: To evaluate and compare the risks of secondary cancers from therapeutic doses received by patients with hepatocellular carcinoma (HCC) during intensity-modulated radiotherapy (IMRT), volumetric arc therapy (VMAT), and tomotherapy (TOMO).

Methods: Treatments for five patients with hepatocellular carcinoma (HCC) were planned using IMRT, VMAT, and TOMO. Based on the Biological Effects of Ionizing Radiation VII method, the excess relative risk (ERR), excess absolute risk (EAR), and lifetime attributable risk (LAR) were evaluated from therapeutic doses, which were measured using radiophotoluminescence glass dosimeters (RPLGDs) for each organ inside a humanoid phantom.

Results: The average organ equivalent doses (OEDs) of 5 patients were measured as 0.23, 1.18, 0.91, 0.95, 0.97, 0.24, and 0.20 Gy for the thyroid, lung, stomach, liver, small intestine, prostate (or ovary), and rectum, respectively. From the OED measurements, LAR incidence were calculated as 83, 46, 22, 30, 2 and 6 per 104 person for the lung, stomach, normal liver, small intestine, prostate (or ovary), and rectum.

Conclusions: We estimated the secondary cancer risks at various organs for patients with HCC who received different treatment modalities. We found that HCC treatment is associated with a high secondary cancer risk in the lung and stomach.

Details

Title
Risk of secondary cancers from scattered radiation during intensity-modulated radiotherapies for hepatocellular carcinoma
Author
Kim, Dong Wook; Chung, Kwangzoo; Chung, Weon Kuu; Bae, Sun Hyun; Shin, Dong Oh; Hong, Seongeon; Park, Sung Ho; Park, Sung-Yong; Hong, Chae-Seon; Lim, Young Kyung; Shin, Dongho; Lee, Se Byeong; Lee, Hyun-ho; Sung, Jiwon; Yoon, Myonggeun
Pages
109
Publication year
2014
Publication date
2014
Publisher
BioMed Central
e-ISSN
1748-717X
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1748-717X-9-109
ProQuest document ID
1527127056
Copyright
© 2014 Kim et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.