Abstract

Reactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expression of EBV lytic proteins, including Rta, Zta, and EA-D and reduces viron production, suggesting that this compound may be useful for preventing the proliferation of the virus.

Details

Title
Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle
Author
Yiu, Ching-Yi; Chen, Shih-Ying; Chang, Li-Kwan; Chiu, Ya-Fang; Lin, Tsuey-Pin
Pages
7115-7124
Publication year
2010
Publication date
2010
Publisher
MDPI AG
e-ISSN
14203049
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1531534757
Copyright
Copyright MDPI AG 2010