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Copyright © 2014 Faezeh Tabesh et al. Faezeh Tabesh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Oats are high in soluble fibers and effective in reducing the risk of cardiovascular diseases (CVD). We assessed the effects of beta-glucan from oat bran on serum nitric oxide (NO) endothelial function in patients with hypercholesterolemia. Method. Sixty hypercholesterolemic patients were randomly divided to receive an experimental bread rich in beta-glucan from oat bran (intervention) or bread rich in wheat fiber (control) for four weeks. All subjects had the same diet for two-week baseline period and hypocaloric diet for four weeks of intervention. Serum NO concentration and flow-mediated dilation (FMD) were determined before and after the experiment. Results. Mean age of the participants was 51.1 ± 9.3 years and 65% ( n = 39 ) were female. After intervention, serum NO concentration increased by 50.2 ± 19.8 μmol/lit in the intervention group ( P = 0.017 ), but no change was observed in the control group (17.5 ± 27.5 μmol/lit; P = 0.530 ). No change of FMD was observed in the intervention (0.48 ± 0.78%; P = 0.546 ) or in the control group (0.59 ± 0.92%; P = 0.533 ). Conclusion. Consumption of oat bread for four weeks increases serum NO concentration but has no effect on FMD. Further studies are warranted in this regard.

Details

Title
The Effects of Beta-Glucan Rich Oat Bread on Serum Nitric Oxide and Vascular Endothelial Function in Patients with Hypercholesterolemia
Author
Tabesh, Faezeh; Sanei, Hamid; Jahangiri, Mansour; Momenizadeh, Amir; Tabesh, Elham; Pourmohammadi, Kiana; Sadeghi, Masoumeh
Publication year
2014
Publication date
2014
Publisher
John Wiley & Sons, Inc.
ISSN
23146133
e-ISSN
23146141
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1552468368
Copyright
Copyright © 2014 Faezeh Tabesh et al. Faezeh Tabesh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.