Abstract

Doc number: 33

Abstract: Osteoarthritis (OA) is considered the most prevalent form of arthritis. The aim of this study was to verify potential protein OA biomarkers by applying Selected Reaction Monitoring (SRM) assays to protein extracts obtained from Bone Marrow-Mesenchymal Stem Cells (BM-MSCs) isolated from OA patients.

BM aspirates were obtained from the femoral channel of OA patients at the time of surgery and from the femoral channel of hip fracture subjects without OA during hip joint replacement surgery for the treatment of subcapital fracture.

SRM results verified the differential expression of several protein biomarkers in BM-MSCs from OA patients.

Details

Title
Selected reaction monitoring assays in mesenchymal stem cells from osteoarthritis patients
Author
Camafeita, Emilio; Lamas, José-Ramón; Calvo, Enrique; Tornero-Esteban, Pilar; López, Juan-Antonio; Fernández-Gutiérrez, Benjamín
Publication year
2014
Publication date
2014
Publisher
BioMed Central
e-ISSN
15590275
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1559-0275-11-33
ProQuest document ID
1561363769
Copyright
© 2014 Camafeita et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.