EHMTI-0140. The potential role of levetiracetam in migraine treatment: an animal study: [Doc 722]

Wang et al. The Journal of Headache and Pain 2014, 15(Suppl 1):F30 http://www.thejournalofheadacheandpain.com/content/15/S1/F30

MEETING ABSTRACT Open Access

EHMTI-0140. The potential role of levetiracetam in migraine treatment: an animal study

YF Wang1*, JC Yen2, LS Kao2, JL Fuh1, SJ Wang1

From 4th European Headache and Migraine Trust International Congress: EHMTIC 2014 Copenhagen, Denmark. 18-21 September 2014

Introduction

Cortical spreading depression (CSD) is one of the most widely used animal models of migraine. Whether levetiracetam (LEV), like other antiepileptic drugs, has a role in the treatment of migraine remains uncertain.

Aim

To investigate the potential of LEV in the treatment of migraine using a rat model of CSD.

Method

Male Sprague-Dawley rats were used. The effects of acute (3 day) and chronic (28 days) treatment with vehicle, LEV 200mg/kg/d, and LEV 400mg/kg/d on CSD susceptibility were examined. Drugs were given as daily intraperitoneal injections. After completion of drug treatment, CSD was elicited by placing a cotton ball soaked with 1M KCl onto the occipital cortex, and was recorded for 2 hours by placing a glass microelectrode into the frontal cortex.

Results

In the acute treatment experiment, rats receiving LEV 400mg/kg/d (8.4 1.0) had fewer CSDs per hour than those receiving vehicle (12.9 1.7, p < 0.001) and LEV 200mg/kg/d (12.5 1.2, p<0.001). In the chronic treatment experiment, rats receiving LEV 400mg/kg/d (11.4 0.6) had fewer hourly CSD events than those receiving vehicle (14.3 0.3, P < 0.001) and LEV 200mg/kg/d(13.6 0.4, p < 0.001), and rats treated LEV 200mg/kg/d had less CSDs than those in the vehicle group (p =0.049).

Conclusion

LEV had a modest effect on reducing CSD susceptibility at a dose of 400mg/kg/d, and the effects on CSD susceptibility were comparable when administered acutely or chronically.

Conflict of interest.

Authors details

1Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan.

2School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Published: 18 September 2014

doi:10.1186/1129-2377-15-S1-F30Cite this article as: Wang et al.: EHMTI-0140. The potential role of levetiracetam in migraine treatment: an animal study. The Journal of Headache and Pain 2014 15(Suppl 1):F30.

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1Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan Full list of author information is available at the end of the article

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