Abstract

Doc number: 314

Abstract: Large cell neuroendocrine carcinoma (LCNC) of the ovary, or ovarian undifferentiated non-small cell carcinoma of neuroendocrine type, is a rare entity that is frequently associated with ovarian surface epithelial tumors. Few cases have been reported in the literature. LCNC is an aggressive tumor with tendency to present at advanced stages and to cause death after a short postoperative duration. We report three cases of LCNC diagnosed histopathologically. Immunohistochemically, the tumor cells were positive for chromogranin A, NSE, CD56, and pancytokeratin. The patients were treated postoperatively with combination chemotherapy. Due to the rarity of LCNC, the general consensus on standard therapy is not established. Although most patients are at stage I, the biological aggressiveness and poor prognosis of the tumors have been reported in previous reports despite extensive surgery and chemotherapy.

Details

Title
Large cell neuroendocrine carcinoma of the ovary: a case report and a brief review of the literature
Author
Ki, Eun Young; Park, Jong Sup; Lee, Keun Ho; Bae, Seog Nyeon; Hur, Soo Young
Publication year
2014
Publication date
2014
Publisher
BioMed Central
e-ISSN
14777819
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1477-7819-12-314
ProQuest document ID
1616259997
Copyright
© 2014 Ki et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.