EHMTI-0097. Long-term outcome in 201 patients with chronic headache with medication overuse: [Doc 940]

Zidverc-Trajkovic et al. The Journal of Headache andPain 2014, 15(Suppl 1):D78 http://www.thejournalofheadacheandpain.com/content/15/S1/D78

MEETING ABSTRACT Open Access

EHMTI-0097. Long-term outcome in 201 patients with chronic headache with medication overuse

J Zidverc-Trajkovic1*, T Pekmezovic2, A Radojicic3, A Podgorac4, N Sternic3

From 4th European Headache and Migraine Trust International Congress: EHMTIC 2014 Copenhagen, Denmark. 18-21 September 2014

From the cohort of 240 patients with chronic headache with medication overuse (MOH), treated with drug withdrawal and prophylactic medications and evaluated at 1-year follow-up, 57.1% were without chronic headache and without medication overuse, 3.3% did not improve after drug withdrawal and 39.6% relapsed developing recurrent overuse (Cephalalgia 2007; 27:1219-25).

The aim of the present study was to evaluate the long-term outcome of these patients.

During the next 1-12 years, follow-up examinations were performed in 201 (83.8%) patients. There were no significant differences between patients lost for further examination and other patients regarding age and gender, as well as the outcome on 1-year follow-up.

On the last follow-up, 66 (32.8%) patients had chronic headache with medication overuse. Without overuse were 130 (64.7%) patients with episodic and five (2.5%) patients with chronic headaches. During the follow-up period, 47 (23.4%) patients had relapsed developing recurrent overuse. The recurrent overuses occurred once in 33 (16.4%), twice in 13 (5.0%) and thrice in four (2.0%) patients. MOH recurrence occurred during the first three years after the first-year follow-up in three quarters of patients. The majority of patients, 33 (70.2%), overused the same medication. Treatment of MOH recurrence was efficacious in 93.6% patients, with strong advice to cease overused drug in 79.0% and prophylactics in 83.0% patients. During the examined period 20 (23.3%) of the patients with MOH on the first-year follow-up had remission of chronic headache with subsequent decrease of medication use.

No conflict of interest.

Authors details

1Headache Center, Neurology Clinic, Belgrade, Serbia. 2Institute of Epidemiology, Faculty of Medicine University of Belgrade, Belgrade, Serbia.

3Headache Centar, Neurology Clinic, Belgrade, Serbia. 4Neurology, Faculty of Medicine University of Belgrade, Belgrade, Serbia.

Published: 18 September 2014

doi:10.1186/1129-2377-15-S1-D78Cite this article as: Zidverc-Trajkovic et al.: EHMTI-0097. Long-term outcome in 201 patients with chronic headache with medication overuse. The Journal of Headache andPain 2014 15(Suppl 1):D78.

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1Headache Center, Neurology Clinic, Belgrade, SerbiaFull list of author information is available at the end of the article

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