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© 2014 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background

During August 2011–February 2012, an outbreak of type Π circulating vaccine-derived poliovirus (cVDPVs) occurred in Sichuan Province, China.

Methods

A field investigation of the outbreak was conducted to characterize outbreak isolates and to guide emergency response. Sequence analysis of poliovirus capsid protein VP1 was performed to determine the viral propagation, and a coverage survey was carried out for risk assessment.

Results

One clinical compatible polio case and three VDPV cases were determined in Ngawa County, Ngawa Tibetan and Qiang Autonomous Prefecture, Sichuan Province. Case patients were unimmunized children, 0.8–1 years old. Genetic sequencing showed that the isolates diverged from the VP1 region of the type Π Sabin strain by 5–12 nucleotides (nt) and shared the same 5 nt VP1 substitutions, which indicate single lineage of cVDPVs. Of the 7 acute flaccid paralysis cases (all>6 months) reported in Ngawa Prefecture in 2011, 4 (57.1%) cases (including 2 polio cases) did not receive oral attenuated poliovirus vaccine. Supplementary immunization activities (SIAs) were conducted in February–May, 2012, and the strain has not been isolated since.

Conclusion

High coverage of routine immunization should be maintained among children until WPV transmission is globally eradicated. Risk assessments should be conducted regularly to pinpoint high risk areas or subpopulations, with SIAs developed if necessary.

Details

Title
An Outbreak of Type Π Vaccine-Derived Poliovirus in Sichuan Province, China: Emergence and Circulation in an Under-Immunized Population
Author
Hai-Bo Wang; Fang, Gang; Wen-Zhou, Yu; Du, Fei; Chun-Xiang, Fan; Qing-Lian, Liu; Li-Xin, Hao; Liu, Yu; Jing-Shan, Zheng; Zhi-Ying Qin; Xia, Wei; Shi-Yue, Zhang; Zun-Dong Yin; Jing, Qiong; Yan-Xia, Zhang; Rong-Na Huang; Ru-Pei, Yang; Wen-Bin, Tong; Qi, Qi; Xu-Jing, Guan; Yu-Lin, Jing; Qian-Li, Ma; Wang, Jin; Xiao-Zhen, Ma; Chen, Na; Hong-Ru, Zheng; Yin-Qiao, Li; Ma, Chao; Qi-Ru, Su; Reilly, Kathleen H; Hui-Ming, Luo; Wu, Xian-Ping; Wen, Ning; Wei-Zhong, Yang
First page
e113880
Section
Research Article
Publication year
2014
Publication date
Dec 2014
Publisher
Public Library of Science
e-ISSN
19326203
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1635249606
Copyright
© 2014 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.