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Environ Health Prev Med (2015) 20:116122 DOI 10.1007/s12199-014-0433-3
REGULAR ARTICLE
Association of serum hs-CRP and lipids with obesity in school children in a 12-month follow-up study in Japan
Ritsuko Nishide Michiko Ando Hidemitsu Funabashi
Yoshiko Yoda Masataka Nakano
Masayuki Shima
Received: 9 July 2014 / Accepted: 27 November 2014 / Published online: 16 December 2014 The Japanese Society for Hygiene 2014
AbstractObjectives To investigate the association of serum lipids and high-sensitivity C-reactive protein (hs-CRP) with obesity in school children and to explore whether hs-CRP levels could be used to predict the presence or absence of obesity 12 months later.
Methods The subjects were school children (611 years old) in Japan. Blood sampling and physical measurements were performed in school (2001); low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and hs-CRP levels were measured. Data from children who could be followed 12 months later were analyzed. Subjects weighing 20 % or more over his/ her standard weight were regarded as obese, and the association of obesity with serum parameters was analyzed.
Results Data from 612 subjects were analyzed (follow-up rate, 75.4 %). The mean of each serum parameter was signicantly higher (inverse for HDL-C; lower) in obese than that in non-obese children. Logistic regression analysis for obesity at baseline showed that the odds ratio (OR) of hs-CRP was the highest [OR, 2.15; 95 % condence interval (CI), 1.652.78 for an interquartile rage (IQR) increase]; the association with triglycerides and LDL-C/ HDL-C was signicant. At the 12-month follow-up, the OR of high hs-CRP remained the highest of all serum parameters (2.09; 95 % CI, 1.632.69 for an IQR increase). Conclusions High levels of triglycerides, LDL-C/HDLC, and hs-CRP increased the risk of obesity in school children. Hs-CRP is considered to be a better predictor of obesity 12 months later than is LDL-C/HDL-C.
Keywords Follow-up Hs-CRP
Low-grade-inammation Obesity School children
Introduction
Serum high-sensitivity C-reactive protein (hs-CRP) has attracted recent attention as a sensitive marker of cardiovascular diseases [1, 2]. Hs-CRP serves as a marker of low-grade inammation in the development of cardiovascular disease and diabetes [35] and predicts vascular risk in healthy women [6]. Elevated serum hs-CRP is associated with obesity and abnormal lipid metabolism in adults. This association has also been conrmed in children [713], although the...