Abstract
The disadvantages of case control observational studies are [3] They are inefficient for rare exposuresInformation on exposure is subject to observation biasThey generally do not allow calculation of incidence (absolute risk)They are subject to selection bias.We would like to thank the authors for their suggestions at the same time we would like to emphasize that in India where recourses are limited taking up large-scale double blind case control RCTs are not always practicable but at the same time we should always try with available recourses to present emerging evidences in clinical practice.
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