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Copyright © 2015 C. Castells-Sala et al. C. Castells-Sala et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ischemia produced as a result of myocardial infarction might cause moderate or severe tissue death. Studies under development propose grafting stem cells into the affected area and we hypothesize that this mechanism could be enhanced by the application of a "bioactive implant." The implant herein proposed consists of a thin porous elastomeric membrane, filled with self-assembling nanofibers and human subcutaneous adipose tissue derived progenitor cells. We describe the development and characterization of two elastomeric membranes: poly(ethyl acrylate) (PEA) and poly(caprolactone 2-(methacryloyloxy)ethyl ester) (PCLMA). Both are a good material support to deliver cells within a soft self-assembling peptide and are elastic enough to withstand the stresses arising from the heartbeat. Both developed composites (PEA and PCLMA, combined with self-assembling peptide) equally facilitate the propagation of electrical pulses and maintain their genetic profile of the seeded cells. Preliminary studies with small animal models suggest that, at short times, the bioimplant shows good adhesion with the myocardium. After three days cells loaded in the patch remain alive at the implanted site. We propose that the bioactive patch (elastomeric membranes with self-assembling peptide and cells) could increase the efficacy of future cardiac cell therapy by improving cell immobilization and survival at the affected site.

Details

Title
Development of Bioactive Patch for Maintenance of Implanted Cells at the Myocardial Infarcted Site
Author
Castells-Sala, C; Valles-Lluch, A; Soler-Botija, C; Arnal-Pastor, M; Martinez-Ramos, C; Fernandez-Muiños, T; Mari-Buye, N; Llucia-Valldeperas, A; Sanchez, B; Chachques, J C; Bayes-Genis, A; M. Monleon Pradas; Semino, C E
Publication year
2015
Publication date
2015
Publisher
John Wiley & Sons, Inc.
ISSN
16874110
e-ISSN
16874129
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1674474456
Copyright
Copyright © 2015 C. Castells-Sala et al. C. Castells-Sala et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.