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The Author(s) 2015

Abstract

Four new 9,19-cycloartane triterpenoids, cimilactone E (1), cimilactone F (2), 2'-O-(E)-butenoyl-23-epi-26-deoxyactein (3), and 2',12[beta]-O-diacetylcimiracemonol-3-O-[beta]-d-xylopyranoside (4), together with four known constituents (5-8) were isolated from the roots of Cimicifuga foetida. The new structures were elucidated by extensive spectroscopic analysis. In addition, compounds 7 and 8 showed significant Wnt signaling pathway inhibitory activity, with IC^sub 50^ values of 3.33 and 13.34 [mu]M, respectively, using the luciferase reporter gene assay.

Details

Title
Cycloartane Glycosides from the Roots of Cimicifuga foetida with Wnt Signaling Pathway Inhibitory Activity
Author
Zhu, Di-fan; Zhu, Guo-lei; Kong, Ling-mei; Bao, Ni-man; Zhou, Lin; Nian, Yin; Qiu, Ming-hua
Pages
61-67
Publication year
2015
Publication date
Feb 2015
Publisher
Springer Nature B.V.
ISSN
21922195
e-ISSN
21922209
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1679431934
Copyright
The Author(s) 2015