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Copyright © 2013 Cibele Bonacorsi et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/

Abstract

Ten Brazilian medicinal plants used to treat gastritis and ulcers were carefully selected on the basis of ethnopharmacological importance and antiulcerogenic activity previously described. The antioxidant activity of the methanolic extracts was determined in analysis conditions that simulate a real biological activity on inhibition of the oxidative burst induced in neutrophils using Helicobacter pylori as activator, by a luminol-amplified chemiluminescence assay. The extracts, at low concentration (5 μg/mL), exhibited a large variation in inhibitory effects of H. pylori-induced oxidative burst ranging from 48% inhibition to inactive, but all extracts, excluding Byrsonima intermedia, had inhibitory activity over 80% at the concentration of 100 μg/mL. The total suppressive antioxidant capacity measured as the effective concentration, which represents the extract concentration producing 50% inhibition of the chemiluminescence induced by H. pylori, varies from 27.2 to 56.8 μg/mL and was in the following order: Qualea parviflora > Qualea multiflora > Alchornea triplinervia > Qualea grandiflora > Anacardium humile > Davilla elliptica > Mouriri pusa > Byrsonima basiloba > Alchornea glandulosa > Byrsonima intermedia. The main groups of compounds in tested extracts are presented. Differences in the phytochemical profile, quantitatively and qualitatively, of these plants can explain and justify their protective effect on the gastric mucosa caused by the neutrophil-generated ROS that occurs when H. pylori displays its evasion mechanisms.

Details

Title
Comparison of Brazilian Plants Used to Treat Gastritis on the Oxidative Burst of Helicobacter pylori-Stimulated Neutrophil
Author
Bonacorsi, Cibele 1 ; Luiz Marcos da Fonseca 2 ; Gonçalves Raddi, Maria Stella 2 ; Rodrigo Rezende Kitagawa 3   VIAFID ORCID Logo  ; Wagner Vilegas 4 

 Instituto de Ciências da Saúde, Universidade Federal de Mato Grosso, 78557-267 Sinop, MT, Brazil 
 Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista (UNESP), 14801-902 Araraquara, SP, Brazil 
 Departamento de Ciências Farmacêuticas, Universidade Federal do Espírito Santo, 29040-090 Vitória, ES, Brazil 
 Campus Experimental do Litoral Paulista, Universidade Estadual Paulista (UNESP), 11330-900 São Vicente, SP, Brazil 
Editor
Ulysses Paulino Albuquerque
Publication year
2013
Publication date
2013
Publisher
John Wiley & Sons, Inc.
ISSN
1741427X
e-ISSN
17414288
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1710741785
Copyright
Copyright © 2013 Cibele Bonacorsi et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/