Abstract

Insulin resistance is one pretty troublesome entity which very commonly aggravates metabolic syndrome. Many methods and indices are available for the estimation of insulin resistance. It is essential to test and validate their reliability before they can be used as an investigation in patients. At present, hyperinsulinemic euglycemic clamp and intravenous glucose tolerance test are the most reliable methods available for estimating insulin resistance and are being used as a reference standard. Some simple methods, from which indices can be derived, have been validated e.g. homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI). For the clinical uses HOMA-insulin resistance, QUIKI, and Matsuda are suitable, while HES, McAuley, Belfiore, Cederholm, Avignon and Stumvoll index are suitable for epidemiological/research purposes. With increasing number of these available indices of IR, it may be difficult for clinicians to select the most appropriate index for their studies. This review provides guidelines that must be considered before performing such studies.

Details

Title
Assessment of insulin sensitivity/resistance
Author
Gutch, Manish; Kumar, Sukriti; Razi, Syed; Gupta, Kumar; Gupta, Abhinav
Publication year
2015
Publication date
Jan-Feb 2015
Publisher
Medknow Publications & Media Pvt. Ltd.
ISSN
22308210
e-ISSN
22309500
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1732323984
Copyright
Copyright Medknow Publications & Media Pvt Ltd Jan-Feb 2015