Abstract

Models of ventricular-arterial coupling (VAC) have historically described the heart as a function of its energetic interaction with the arterial system. However, these models either represent the dynamic, adaptive cardiovascular system (CVS) in isolation or sacrifice cardiac mechanics to use simplified, time-averaged values across the cardiac cycle. In this thesis a facsimile CVS is constructed that characterizes ventricular-arterial interactions with intact cardiac mechanics as a function of whole-body thermo-fluid homeostatic regulation. Simulation results indicate proportional-integral (PI) control of heart rate and arterial resistance is conditionally sufficient to maintain body temperature during square-wave exercise, but further elements may be required to mimic genuine physiological responses. These simulations of the primitive model lay the framework of capillary-centric VAC through the perspective of coupling-as-thermodynamics.

Details

Title
The capillary-centric model of cardiac coupling-as-thermodynamics
Author
Taylor, Andrew James David  VIAFID ORCID Logo 
Year
2015
Publisher
ProQuest Dissertations & Theses
ISBN
978-1-339-36322-6
Source type
Dissertation or Thesis
Language of publication
English
ProQuest document ID
1752512222
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.