Abstract

Background

In this study discussed the primary and regulatory roles of fatty acids, and investigated the affects of fatty acids on metabolic programming.

Methods

Review of the literature was carried out on three electronic databases to assess the roles of fatty acids in metabolic programming. All abstracts and full-text articles were examined, and the most relevant articles were selected for screening and inclusion in this review.

Results

The mother's nutritional environment during fetal period has important effects on long term health. Fatty acids play a primary role in growth and development. Alterations in fatty acid intake in the fetal period may increase the risk of obesity and metabolic disorders in later life. Maternal fatty acid intakes during pregnancy and lactation are passed to the fetus and the newborn via the placenta and breast milk, respectively. Imbalances in fatty acid intake during the fetal period change the fatty acid composition of membrane phospholipids, which can cause structural and functional problems in cells. Additionally, the metabolic and neuroendocrine environments of the fetus and the newborn play key roles in the regulation of energy balance.

Conclusions

Imbalances in fatty acid intake during pregnancy and lactation may result in permanent changes in appetite control, neuroendocrine function and energy metabolism in the fetus, leading to metabolic programming. Further studies are needed to determine the role of fatty acid intake in metabolic programming.

Details

Title
Do fatty acids affect fetal programming?
Author
Kabaran, Seray; Besler, H Tanju
Pages
n/a
Publication year
2015
Publication date
2015
Publisher
BioMed Central
ISSN
16060997
e-ISSN
20721315
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1767943164
Copyright
Copyright BioMed Central 2015