Urticaria as initial finding of a patient with carcinoid tumor

Abstract

Carcinoid tumors are rare, slow-growing neuroendocrine tumors arising from the enterochromaffin cells. They are most commonly found in the gastrointestinal tract (64 %) [1], although they can involve any organ. These tumors can secrete biogenic amines and peptides, such as ACTH, 5-HTP and serotonin [2]. Classical carcinoid syndrome occurs in <10 % of patients with carcinoid tumors. Its most typical clinical manifestations include cutaneous flushing, most often on the face, neck, and upper chest, diarrhea and abdominal pain [3]. Other manifestations may occasionally be encountered, including bronchial asthma, wheezing, or very rarely, skin manifestations [4].