Neuroinflammation in Parkinsons disease and its potential as therapeutic target

Abstract

[...]the precise role of inflammation in PD is still not fully understood. [...]the inflammatory responses in PD refer to both glial activation and peripheral immune cell infiltration, but the relationship between these two different inflammatory pathways is still unclear. [...]the different forms of microglia activation further increase the difficulty and complexity of manipulation of microglial responses in PD. A better understanding of how these two activated phenotypes of microglia contribute to PD progression may provide a basis for future drug discoveries.