Differences in glutamate receptors and inflammatory cell numbers are associated with the resolution of pain in human rotator cuff tendinopathy

Abstract

Tendon pain is more common in people with rotator cuff tears than those with normal tendons [4], however there is a poor association between the severity of symptoms and extent of structural change [5, 6] and current non-operative strategies are focused on steroid-based therapies with mixed results. Oxford Shoulder Score PGP9.5: protein gene product 9.5 PTT: partial-thickness tear RCT: rotator cuff tendinopathy SAD: subacromial decompression TNF-?: tumour necrosis factor alpha Declarations Acknowledgements The authors of this work are funded by the Musculoskeletal Biomedical Research Unit of the National Institute for Health Research (BD, SGD, SS, RM, MJ and AC), Arthritis Research UK (SGD 20506 and SS 20087), the Jean Shanks Foundation (BD) and Orthopaedic Research UK (BD).