Abnormal villous morphology mimicking a hydatidiform mole associated with paternal trisomy of chromosomes 3,7,8 and unipaternal disomy of chromosome 11

Abstract

[...]we demonstrate that absent p57KIP2 immunostaining indicates loss of maternal gene expression from the p57KIP2 region on chromosome 11, rather than CHM. [...]we confirm the diagnostic importance of selective molecular genetic testing for providing definitive diagnosis in cases of possible HM in which morphological features are non-diagnostic.