Prognosis of mechanically ventilated patients entering the weaning process

Abstract

Issue Title: ESICM LIVES 2015

Beduneau et al. Intensive Care Medicine Experimental 2015, 3(Suppl 1):A426

http://www.icm-experimental.com/content/3/S1/A426

POSTER PRESENTATION Open Access

Prognosis of mechanically ventilated patients entering the weaning process

G Beduneau1*, T Pham2*, JCM Richard3, F Schortgen4, JM Chretien5, A Mercat6, J Mancebo7, L Brochard8,

WIND Study Group on behalf of REVA Network From ESICM LIVES 2015

Berlin, Germany. 3-7 October 2015

Introduction

The WIND study Weaning according to New Definition prospectively collected epidemiologic data concerning mechanical ventilation (MV) and weaning. The aim of the present analysis was to specifically address mortality at the different pre-defined steps of the weaning process.

Methods

This is a subsequent analysis of the original prospective observational study run in 36 intensive care units in France, Spain and Switzerland over a three month period. All patients requiring intubation and MV were enrolled. MV modality, results of spontaneous breathing trials (SBT) and extubation, therapeutic limitation as well as survival were daily collected until ICU discharge or day 60. A weaning attempt (WA) was defined either by a spontaneous breathing trial or a direct extubation (planned or unplanned). Weaning success was defined as discharged alive without mechanical ventilation within the 7 days following extubation. The prognosis of patients at the key steps of the weaning process was analysed as mortality at ICU discharge or D60.

Results

2729 patients were enrolled and 20 specifically intubated for upper airway obstacle were excluded. 2709 patients

were analysed among whom 2051 entered the weaning process (i.e. had at least one WA). Prognosis is reported on table 1 for the whole cohort, for the patients entering weaning, after failure of the first WA and for the patients still ventilated 7 days after the first WA.

Conclusions

Based on this large cohort of intubated patients, mortality was 10% for the patients entering the weaning process but was three times higher (33%) in patients failing their 1st

WA; 63% of the deaths occurred within one week after the failed WA. The present analysis is the first to document mortality along different steps of the weaning process as experienced in daily practice.

Grant Acknowledgment

Association daide aux insuffisants respiratoires (Rouen, France)

*GB and TP are considered both as first authors.

Authors details

1University Hospital, Rouen, France. 2Medical and Surgical Intensive Care, Hpital Tenon, APHP, Paris, France. 3Annecy Genevois General Hospital, Annecy, France. 4Medical ICU, CHU Henri Mondor, APHP Paris, Paris, France.

5Clinical Research Institute Angers Universitary Hospital, Angers, France.

6Medical Intensive Care, Universitary Hospital Angers, Angers, France.

7Hospital de Sant Pau, Barcelona, Spain, Barcelona, Spain. 8Saint Michaels

Table 1. After failure of 1st WA, 125 patients (among the 197 dead) died in the seven first days

Intubated patients Entering weaning (WA) Failure 1st WA Still ventilated 7 days after 1st WA Patients (N) 2709 2051 605 218Mortality, % (N) 28 (771) 10 (205) 33 (197) 28 (62)

1University Hospital, Rouen, France

2Medical and Surgical Intensive Care, Hpital Tenon, APHP, Paris, France Full list of author information is available at the end of the article

2015 Beduneau et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0

Web End =http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Beduneau et al. Intensive Care Medicine Experimental 2015, 3(Suppl 1):A426

http://www.icm-experimental.com/content/3/S1/A426

Page 2 of 2

Hospital and Keenan Research Centre, Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada.

Published: 1 October 2015

doi:10.1186/2197-425X-3-S1-A426Cite this article as: Beduneau et al.: Prognosis of mechanically ventilated patients entering the weaning process. Intensive Care Medicine Experimental 2015 3(Suppl 1):A426.

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