Molecular characteristics of Human Endogenous Retrovirus type-W in schizophrenia and bipolar disorder

Citation: Transl Psychiatry (2013) 3, e224; doi:10.1038/tp.2013.1

& 2013 Macmillan Publishers Limited All rights reserved 2158-3188/13 http://www.nature.com/tp

Web End =www.nature.com/tp

CORRIGENDUM

Molecular characteristics of Human Endogenous Retrovirus type-W in schizophrenia and bipolar disorder

H Perron, N Hamdani, R Faucard, M Lajnef, S Jamain, C Daban-Huard, S Sarrazin, E LeGuen, J Houenou, M Delavest, H Moins-Teisserenc, D Bengoufa, R Yolken, A Madeira, M Garcia-Montojo, N Gehin, I Burgelin, G Ollagnier, C Bernard, A Dumaine, A Henrion, A Gombert, K Le Dudal, D Charron, R Krishnamoorthy, R Tamouza and M Leboyer

Translational Psychiatry (2013) 3, e224; doi:http://dx.doi.org/10.1038/tp.2013.1

Web End =10.1038/tp.2013.1 ; published online 22 January 2013

Correction to: Translational Psychiatry (2012) 2, e201; doi:http://10.1038/tp.2013.1

Web End =10.1038/tp.2012.125 ; published online 4 December 2012.

In the Patients and Methods section, under MSRV-env genomic DNA copy number in total blood leukocytes by real-time PCR, the paragraph Results, representing the MSRV DNA copy number per diploid human genome, were obtained by calculating the ratio between HERV-W/MSRV copies and hydroxymethylbilane synthase copies in the same sample should have appeared as follows:

Relative gene quantication was performed using the 2-DDCT method (Livak and Schmittgen, Methods 2001; 25: 402408). With this method, the DNA of an unaffected individual has been used as a calibrator in order to normalize all reactions, and HBMS was used as a diploid internal control

for each DNA sample as follows: 2-((Ct MSRV Ct HBMS) (Ctcal MSRVCtcal HBMS)). The results are thus expressed as a proportion of HERV-W DNA copy number as compared with the calibrator, representative of the healthy control population.

In addition, in Figure 2, the y-axis label of panel a and the x-axis label on the three graphs in panel b were incorrect. In all four places, they should read MSRV-env DNA relative quantication. The rst two sentences in the description of panel a should read Relative gene quantication in DNA of patients and controls, according to the 2-DDCT method (Livak and Schmittgen, Methods 2001; 25: 402408), is indicated on the y axis. The rst sentence in the description of panel b should read Distribution of HERV-W env relative gene quantication in patients and controls.