The Patient's Guide to Psoriasis Treatment. Part 4: Goeckerman Therapy

Abstract

Background

The Goeckerman regimen remains one of the oldest, most reliable treatment options for patients with moderate to severe psoriasis. Goeckerman therapy currently consists of exposure to ultraviolet B light and application of crude coal tar. The details of the procedure can be confusing and challenging to understand for the first-time patient or provider.

Objective

To present a freely available online guide and video on Goeckerman treatment that explains the regimen in a patient-oriented manner.

Methods

The Goeckerman protocol used at the University of California--San Francisco Psoriasis and Skin Treatment Center as well as available information from the literature were reviewed to design a comprehensive guide for patients receiving Goeckerman treatment.

Results

We created a printable guide and video resource that covers the supplies needed for Goeckerman regimen, the treatment procedure, expected results, how to monitor for adverse events, and discharge planning.

Conclusion

This new resource is beneficial for prospective patients planning to undergo Goeckerman treatment, healthcare providers, and trainees who want to learn more about this procedure. Online media and video delivers material in a way that is flexible and often familiar to patients.

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The Patients Guide to Psoriasis Treatment. Part 4: Goeckerman Therapy

Tian Hao Zhu . Mio Nakamura . Benjamin Farahnik . Michael Abrouk .

Rasnik K. Singh . Kristina M. Lee . Sarah Hulse . John Koo .

Tina Bhutani . Wilson Liao

Received: May 6, 2016 / Published online: July 29, 2016 The Author(s) 2016. This article is published with open access at Springerlink.com

ABSTRACT

Background: The Goeckerman regimen remains one of the oldest, most reliable treatment options for patients with moderate to severe psoriasis. Goeckerman therapy currently consists of exposure to ultraviolet B light and application of crude coal tar. The details of the procedure can be confusing and

challenging to understand for the rst-time patient or provider.

Objective: To present a freely available online guide and video on Goeckerman treatment that explains the regimen in a patient-oriented manner.

Methods: The Goeckerman protocol used at the University of CaliforniaSan Francisco Psoriasis and Skin Treatment Center as well as available information from the literature were reviewed to design a comprehensive guide for patients receiving Goeckerman treatment. Results: We created a printable guide and video resource that covers the supplies needed for Goeckerman regimen, the treatment procedure, expected results, how to monitor for adverse events, and discharge planning.

Conclusion: This new resource is benecial for prospective patients planning to undergo Goeckerman treatment, healthcare providers, and trainees who want to learn more about this procedure. Online media and video delivers material in a way that is exible and often familiar to patients.

Keywords: Goeckerman therapy; Patient education; Psoriasis; Tar; Video guide

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T. H. Zhu (&)

University of Southern California Keck School of Medicine, Los Angeles, CA, USAe-mail: [email protected]

M. Nakamura K. M. Lee S. Hulse J. Koo

T. Bhutani W. Liao

Department of Dermatology, Psoriasis and Skin Treatment Center, University of California-San Francisco, San Francisco, CA, USA

B. FarahnikUniversity of Vermont College of Medicine, Burlington, VT, USA

M. AbroukUniversity of California-Irvine, School of Medicine, Irvine, CA, USA

R. K. SinghUniversity of California-Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

334 Dermatol Ther (Heidelb) (2016) 6:333339

INTRODUCTION

The Goeckerman regimen is a unique combination therapy of ultraviolet B (UVB) light and application of crude coal tar (CCT) for the treatment of psoriasis [1, 2]. First introduced in 1925, the Goeckerman regimen remains one of the oldest, most reliable treatment options for patients with moderate to severe psoriasis [3]. The advantage in using tar and phototherapy together is that tar is a photosensitizer and when combined with UVB light acts synergistically to produce better results than either treatment alone [35]. In comparison to other treatment modalities such as internal biologic agents, oral systemic agents, and topical medications, Goeckerman therapy remains extremely effective with relatively few side effects. This makes Goeckerman regimen an excellent alternative for patients who may have previously failed multiple therapies, the elderly, pregnant patients, children, and the immunosuppressed [6].

Goeckerman therapy was originally administered at an inpatient hospital facility for 24 h a day for multiple days until the psoriasis cleared [2]. However, patients today are often treated in an outpatient day care setting where they return home at the end of the treatment day with similar results but signicantly reduced cost [6, 7]. Currently, Goeckerman therapy at the University of CaliforniaSan Francisco (UCSF) Psoriasis Center requires a minimum time commitment of 45 h in the daycare facility for 5 days a week for 6 weeks for a total of 30 total treatment days [1]. The major limitation of this therapy is the time commitment required as patients should avoid interruption in their therapy, which can delay complete treatment of their psoriasis lesions and shorten the remission time.

Nevertheless, almost all Goeckerman patients have seen signicant improvement in their skin condition over the duration of their therapy.

In a study performed at the University of California San Francisco (UCSF) Psoriasis and Day Care Center 100% of patients receiving Goeckerman over a 12 week period achieved a 75% or greater improvement in their psoriasis lesions [8]. Another advantage of Goeckerman is the long period of remission following completion of therapy, which can last between 8 months to over a year [6, 9]. Studies have also shown that Goeckerman therapy can signicantly increase patient satisfaction and improve overall quality of life [10]. In addition, UCSF has developed a modied Goeckerman regimen to treat other skin diseases such as eczema, prurigo nodularis, and pruritus [11, 12].

For the rst-time patient or referring provider the details of the Goeckerman procedure can be confusing and challenging to understand. Therefore, the following guide and online media attempt to deliver the material in a way that is easily understandable and readily accessible. Below we will describe supplies for Goeckerman therapy, evaluation and preparation, treatment procedure, daily assessment, discharge planning, and safety considerations.

METHODS

We reviewed the Goeckerman therapy protocol used at the UCSF Psoriasis and Skin Treatment Center. In addition PubMed database was searched using the term psoriasis combined with the term Goeckerman therapy, tar therapy, or tar and light therapy to identify relevant articles to design a comprehensive guide for patients receiving Goeckerman treatment.

Dermatol Ther (Heidelb) (2016) 6:333339 335

This article does not contain any new studies with human or animal subjects performed by any of the authors. All photos are printed with the consent of the subject(s).

Table 1 Supplies for Goeckerman regimen

Crude coal tar(2%, 5%, 10%) black tar

White petrolatum ointment Cetaphil cream

Aquaphor ointment

Cetaphil creamVanicream lotionTopical corticosteroids Clobetasol propionate 0.05%

ointment

Triamcinolone 0.01% ointment Desonide 0.05% ointmentTar removal Mineral oil

SoapMoisturizing lotion Aquaphilic ointment

Vanicream Occlusion Plastic wrap

Miscellaneous Gown

Gloves Socks

Shower cap

RESULTS AND DISCUSSION

Liquor carbonis detergens (20%) gold tar

Overview

The guide below will cover the supplies needed for Goeckerman regimen, the treatment procedure, how to monitor for side effects, daily assessment, and discharge planning.

Supplies for the Goeckerman Regimen

Tar used for Goeckerman is available in two forms. CCT, commonly referred to as black tar, is compounded in white petrolatum ointment or Cetaphil cream (Galderma Laboratories, L.P.) in concentrations of 2%, 5%, and 10%. Liquor carbonis detergens (LCD), commonly referred to as gold tar, is compounded in Aquaphor ointment (Beiersdorf, Inc.), Cetaphil cream, or VanicreamTM lotion (Pharmaceutical Specialties, Inc.) as 20% concentration. Topical steroids include clobetasol propionate 0.05% ointment, triamcinolone 0.01% ointment, and desonide 0.05% ointment. Mineral oil is used for washing topical medications off. Moisturizing lotion used after therapy consists of Aquaphilic ointment (Medco Lab Inc.) or Vanicream. Plastic wrap is used for occlusion purposes. Gown, gloves, socks, and shower cap are used for covering the skin (Table 1).

Evaluation and Preparation

Prior to therapy a complete history and physical examination is performed for each patient to

obtain important information on current and past medications, response to previous psoriasis therapies, history of adverse reactions to sunlight or phototherapy, and severity of itch. An initial assessment of the skin will help to determine the degree and severity of psoriasis involvement and whether patients display widespread or intense erythema. In cases of severe psoriasis it is recommended that patients undergo a cool down period during which topical corticosteroids will be applied to the affected areas and occluded with plastic wrap until the erythema is greatly reduced (314 days) [1, 11]. This is because UV light and tar preparations have the potential to worsen acutely inamed psoriasis (Table 2).

336 Dermatol Ther (Heidelb) (2016) 6:333339

Table 2 Evaluation and preparation

Obtain history and physicalAssess for degree and severity of skin involvement

Perform optional cool down period

Table 3 Treatment procedure

Patient checks in at front desk

;

Nurse administers UVB phototherapy

;

Patient asked to undress for tar application

;

Nurse applies CCT to body and extremities and LCD to the scalp

;

Tar is occluded with plastic wrap

;

Patient dressed in gown with gloves, socks, and shower cap

;

Therapy continues for 45 h

;

Tar is washed off with mineral oil and soap

;

Nurse applies LCD to the body before patient leaves for home

CCT crude coal tar, LCD liquor carbonis detergens, UVB ultraviolet B

Treatment Procedure

After the cool down procedure (if needed), the nurse will administer phototherapy in the morning each day before applying tar to affected areas of the skin. Narrowband UVB is most commonly used although broadband UVB may be used in certain situations where narrowband UVB is ineffective or not tolerated by the patient [5, 8]. The initial phototherapy dose is determined by the patients Fitzpatrick skin type. A nurse will then adjust subsequent phototherapy dosing according to the patients response and tolerance to phototherapy, noting any signs of skin burning or itching (Table 3).

After phototherapy, CCT will be applied to affected areas of the body and LCD for scalp involvement. Tar is typically started with the lowest concentration available and increased gradually as tolerated by the patient. Some patients may not tolerate CCT or LCD in Aquaphor base due to the greasy texture or alcohol content [11, 13]. For these patients, tar in Cetaphil cream, a water based moisturizer-may be substituted. A formulation of tar compounded with salicylic acid is often used in areas with greatly thickened plaques to help reduce the scaling. However, salicylic acid should be used with caution in patients with diabetes or gastric ulcers due to the potential for adverse side effects [14].

Occlusion of topical tar is then performed with plastic wrap to the body, arms, and legs, impermeable gloves for the hands, socks for the

feet, and a shower cap for the scalp (Fig. 1). Topical tar is typically left on the skin for a minimum of 45 h each day. During this time, patients may read, listen to music, work on a laptop computer, socialize with other Goeckerman patients, or participate in group activities such as meditation, board games, or cooking (Fig. 2). After the 45 h period, the tar is washed off in the shower with mineral oil and soap. After Goeckerman therapy is completed at the daycare center a nurse will apply LCD in Aquaphor ointment or Cetaphil cream (less greasy option) to the body before the patient leaves for home.

Dermatol Ther (Heidelb) (2016) 6:333339 337

Daily Assessment

Each day the patient will be assessed by the care team consisting of a doctor, fellow, and nurse for response to Goeckerman treatment. Signs of skin burn such as redness of the skin, skin tightness, pain, and rarely blistering may indicate too high a dose or intolerance to light therapy [1]. If a burning sensation develops, the phototherapy dose is either decreased or phototherapy treatment is not given at all for that day. Itch is another common concern as skin irritation may be a sign of sensitivity from tar or plastic wrap, in which case the concentration of tar may be decreased or the wrap may not be applied. Patients are also encouraged at this time to update their care team about any change in their medical conditions that may have occurred or outside doctors visits they may have had (Table 4).

Discharge Planning

Upon completion of the Goeckerman course, patients will be started on a maintenance program which may include outpatient phototherapy three times a week for the rst month with gradual taper and topical medications to be applied at home. One month after completion of Goeckerman the patient will be scheduled for a follow-up visit with the doctor (Table 5).

Fig. 1 Supplies for Goeckerman regimen. Left side gown, socks, shower cap. Top row Mineral oil, Aquaphilic ointment, Vanicream, plastic wrap. Middle row 20% liquid carbonis detergens in Vanicream lotion, 20% liquid carbonis detergens in Aquaphor ointment, 5% crude coal tar in white petrolatum ointment, triamcinolone 0.01% ointment. Bottom row Desonide 0.05% ointment, clobetasol propionate 0.05% ointment

Fig. 2 Treatment procedure. a Nurse occluding tar with plastic wrap. b Patient spends 45 h in waiting area during tar therapy

Table 4 Daily assessment

Team of doctor, fellows, and nurses evaluate patient response to treatment

Check for signs of skin burn and itchAdjust phototherapy dosing and tar concentration as appropriate

338 Dermatol Ther (Heidelb) (2016) 6:333339

Table 5 Discharge planning

Home maintenance program with outpatient phototherapy, LCD, and topical steroids

Reassess patient response to therapy after 1 month

LCD liquor carbonis detergens

CONCLUSIONS

Safety Considerations

The safety prole of Goeckerman therapy is excellent with relatively few side effects. One of the main concerns regarding coal tar is the theoretical carcinogenic potential. However, many studies including a review of 13,200 patients undergoing Goeckerman regimen for psoriasis and eczema showed that there is no increased risk of cancer with tar therapy compared to topical corticosteroids [13]. In addition, Goeckerman therapy is entirely topical and has limited internal absorption, so it does not increase the risk for cardiovascular disease, tuberculosis, or serious infections that may be associated with some oral or injectable medications [15]. The most commonly observed side effects include mild folliculitis, a skin condition characterized by itchy red bumps that develop around hair follicles, and mild skin burning from the UVB light [1]. For this reason it is recommended that

patients avoid extended periods of sun exposure when tar is applied at home (Table 6).

Goeckerman therapy is both safe and effective for treatment of moderate to severe psoriasis and is an excellent treatment option. Nevertheless, Goeckerman therapy requires a rm time commitment by the patient. Patients are encouraged to fully participate in this program by showing up daily, not missing therapy sessions, and communicating any symptoms or concerns to the care staff. With consistent adherence to therapy, the vast majority of patients can achieve total body clearing, even in the toughest areas such as the scalp, palms, and soles. This guide and the corresponding online video serves to orient and educate prospective patients planning to start Goeckerman treatment, healthcare providers, and trainees who want to learn more about this procedure.

ACKNOWLEDGMENTS

Table 6 Safety considerations

Side effect Signs/symptoms

Skin burninga Redness, tenderness, pain, tightness, itching, rarely blistering

Noticeable 46 h after treatment with

UVB phototherapyFolliculitis Itchy red bumps that develop around hair follicles

Itching Skin irritation from tar or occlusion

UVB ultraviolet B

a Patients should avoid extended periods of sun exposure when tar is applied at home

We would like to thank Tim Sarmiento for producing, directing, and editing the educational video that accompanies this manuscript. We would also like to thank the amazing staff and nurses from the UCSF Psoriasis and Skin Treatment Center for inspiring and helping make the video possible. We thank Olivia Chen for her help reviewing the Spanish translation of the accompanying video. No funding or sponsorship was received for publication of this article. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this manuscript, take responsibility for the integrity of the work as a whole, and have given nal approval for the version to be published.

Dermatol Ther (Heidelb) (2016) 6:333339 339

Disclosures. John Koo is a speaker for AbbVie, Leo, and Celgene, and conducts research for Amgen, Janssen, Novartis, Photomedex, Galderma, Pzer and Merck. Tina Bhutani is an advisor for Cutanea, and conducts research for Abbvie, Janssen, and Merck. Wilson Liao conducts research for Abbvie, Janssen, Novartis, and Pzer, and receives funding from the NIH (R01AR065174, U01AI119125). John Koo, Tina Bhutani, and Wilson Liao have no stocks, employment or board memberships with any pharmaceutical company. Tian Hao Zhu, Mio Nakamura, Benjamin Farahnik, Michael Abrouk, Rasnik K. Singh, Kristina M. Lee, and Sarah Hulse have nothing to disclose.

Compliance with Ethics Guidelines. This article does not involve any new studies of human or animal subjects performed by any of the authors. All photos are printed with the consent of the subject(s).

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