Abstract

Background: Imaging mass spectrometry (IMS) generates molecular images directly from tissue sections to provide better diagnostic insights and expand the capabilities of clinical anatomic pathology. Although IMS technology has matured over recent years, the link between microscopy imaging currently used by pathologists and MS-based molecular imaging has not been established. Methods: We adapted the Vanderbilt University Tissue Core workflow for IMS into a web-based system that facilitates remote collaboration. The platform was designed to perform within acceptable web response times for viewing, annotating, and processing high resolution microscopy images. Results: We describe a microscopy-driven approach to tissue analysis by IMS. Conclusion: The Pathology Interface for Mass Spectrometry is designed to provide clinical access to IMS technology and deliver enhanced diagnostic value.

Details

Title
Pathology interface for the molecular analysis of tissue by mass spectrometry
Author
Norris, Jeremy; Tsui, Tina; Gutierrez, Danielle; Caprioli, Richard
Publication year
2016
Publication date
2016
Publisher
Medknow Publications & Media Pvt. Ltd.
ISSN
22295089
e-ISSN
21533539
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1818442359
Copyright
Copyright Medknow Publications & Media Pvt Ltd 2016