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© 2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Mofenson LM (2016) Tenofovir Pre-exposure Prophylaxis for Pregnant and Breastfeeding Women at Risk of HIV Infection: The Time is Now. PLoS Med 13(9): e1002133. doi:10.1371/journal.pmed.1002133

Abstract

The approved drug label for TDF states that the drug "should be used during pregnancy only if clearly needed...Because of both the potential for HIV-1 transmission and the potential for serious adverse reactions in nursing infants, mothers should be instructed not to breastfeed if they are receiving [the drug]" [4]. [...]there is a critical need to examine the safety of PrEP in HIV-uninfected pregnant and breastfeeding women (particularly adolescent and young women) and their infants. Tenofovir, the active drug moiety of TDF, has very low bioavailability, and it is therefore administered as the water-soluble prodrug to increase permeability across epithelial barriers and, once absorbed, is rapidly converted to tenofovir. Because it is the active drug that is present in maternal blood, it would be expected that there would be low penetration of tenofovir across the blood-breast epithelial barrier into breast milk.

Details

Title
Tenofovir Pre-exposure Prophylaxis for Pregnant and Breastfeeding Women at Risk of HIV Infection: The Time is Now
Author
Mofenson, Lynne M
Section
Perspective
Publication year
2016
Publication date
Sep 2016
Publisher
Public Library of Science
ISSN
15491277
e-ISSN
15491676
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1829451183
Copyright
© 2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Mofenson LM (2016) Tenofovir Pre-exposure Prophylaxis for Pregnant and Breastfeeding Women at Risk of HIV Infection: The Time is Now. PLoS Med 13(9): e1002133. doi:10.1371/journal.pmed.1002133