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Copyright Tabriz University of Medical Sciences 2016

Abstract

According to Guide for Care and Use of Laboratory Animals [U.S. Department of Health, Education, and Welfare (DHEW), Publication number 78-23, National Institutes of Health (NIH), revised 1978] and local guidelines for compassionate use of animals in research, two rats were housed per cage, provided with free access to tap water and compact standard chow. [...]PKC activation can induce MCP-1 synthesis. Since MCP1 1 the strongest chemotactic factor for the monocytes, its over-expression would lead to the increase of monocyte immigration and monocyte activity and exacerbate interstitial fibrosis, thereby deteriorating renal function.14 Jiao et al. in their study14 showed that Val could decrease TGF-β 1 and MCP-1 expression and oxidative stress in glomerular mesangial cells and glomerular epithelial cells cultured in high-glucose and oxidative stress conditions.

Details

Title
The effects of valsartan on renal glutathione peroxidase expression in alleviation of cyclosporine nephrotoxicity in rats
Author
Raeisi, Sina; Ghorbanihaghjo, Amir; Argani, Hassan; Dastmalchi, Siavoush; Ghasemi, Babollah; Ghazizadeh, Teimour; Rashtchizadeh, Nadereh; Abbasi, Mehran Mesgari; Bargahi, Nasrin; Nemati, Mahboob; Mota, Ali; Vatankhah, Amir Mansour
Pages
119-124
Publication year
2016
Publication date
2016
Publisher
Tabriz University of Medical Sciences
ISSN
22285652
e-ISSN
22285660
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1841298627
Copyright
Copyright Tabriz University of Medical Sciences 2016