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Copyright Nature Publishing Group Jan 2017

Abstract

Colorectal carcinoma (CRC) is the one of the most common cancers with considerable metastatic potential, explaining the need for new drug candidates that inhibit tumor metastasis. The signal transducers and activators of the transcription 3 (Stat3) signaling pathway has an important role in CRC and has been validated as a promising anticancer target for CRC therapy. In the present study, we report our findings on nifuroxazide, an antidiarrheal agent identified as an inhibitor of Stat3. Our studies showed that nifuroxazide decreased the viability of three CRC cell lines and induced apoptosis of cancer cells in a concentration-dependent manner. Moreover, western blot analysis demonstrated that the occurrence of its apoptosis was correlated with the activation of Bax and cleaved caspase-3, and decreased the expression of Bcl-2. In addition, nifuroxazide markedly impaired CRC cell migration and invasion by downregulating phosphorylated-Stat3Tyr705, and also impaired the expression of matrix metalloproteinases

Details

Title
Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis
Author
Ye, Ting-hong; Yang, Fang-fang; Zhu, Yong-xia; Li, Ya-li; Lei, Qian; Song, Xue-jiao; Xia, Yong; Xiong, Ying; Zhang, Li-dan; Wang, Ning-yu; Zhao, Li-feng; Gou, Hong-feng; Xie, Yong-mei; Yang, Sheng-yong; Yu, Luo-ting; Yang, Li; Wei, Yu-quan
Pages
n/a
Publication year
2017
Publication date
Jan 2017
Publisher
Springer Nature B.V.
e-ISSN
20414889
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1855313889
Copyright
Copyright Nature Publishing Group Jan 2017