Abstract

A 46-year-old female who lost her native kidney function due a biopsy proven collapsing type of FSGS, had a living kidney transplant after which, she developed acute renal allograft dysfunction, thrombocytopenia and microangiopathichemolytic anemia five days post-transplant. Renal biopsy revealed acute antibody-mediated rejection (AMR). Genetic studies showed that this patient has a homozygous mutation of complement factor B (CFB) gene and heterozygous variant of C 3 gene consistent with atypical hemolytic uremic syndrome type 4. Intravenous immunoglobulin (IV IG) and plasma exchange did not resolve these abnormalities. Eculizumab and bortezomib, on other hand, were very effective.

Details

Title
Antibody-mediated rejection and aHUS in renal graft recipient
Author
Hafez, Ibrahim 1   VIAFID ORCID Logo  ; Salem Al Qurashi 1 ; Mubarak Abdullah 1 ; Hajeer, Ali 2 ; Alsaad, Khaled O 2 ; Abdulla Al Sayyari 1 

1  Department of Medicine, King Saud Bin Abdulaziz University for Health Sciences, P.O. Box 22490, Riyadh 11426, Saudi Arabia 
2  Department of Laboratory Medicine, King Saud Bin Abdulaziz University for Health Sciences, P.O. Box 22490, Riyadh 11426, Saudi Arabia 
Publication year
2016
Publication date
Dec 2016
Publisher
Taylor & Francis Ltd.
e-ISSN
2331205X
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1080/2331205X.2016.1215014
ProQuest document ID
1860813512
Copyright
© 2016 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.