Abstract

The electrochemical oxidation of carbenicillin disodium salt (CDS) at gold electrode has been investigated for the first time using cyclic, linear sweep, and differential pulse voltammetric techniques. The dependence of the current on pH, concentration, and scan rate were investigated to optimize the experimental conditions for the determination of carbenicillin. The anodic peak was characterized and process was adsorption-controlled. The number of electrons transferred in the oxidation was calculated. A differential pulse voltammetry method with good precision and accuracy was developed for the determination of carbenicillin. The anodic peak current varied linearly with carbenicillin concentration in the range 1.0 × 10−4 M to 5.0 × 10−6 M with a limit of detection (LOD) of 6.859 × 10−7 M and limit of quantification (LOQ) of 2.286 × 10−6 M. This method can be employed in clinical analysis, quality control, and routine determination of drugs in pharmaceutical analysis.

Details

Title
Voltammetric oxidation of carbenicillin and its electro analytical applications at gold electrode
Author
Meti, Manjunath D 1 ; Abbar, Jyothi C 1 ; Nandibewoor, Sharanappa T 1 ; Chimatadar, Shivamurti A 1   VIAFID ORCID Logo 

1  Department of Studies in Chemistry, Karnatak University, Dharwad 580003, India 
Publication year
2016
Publication date
Dec 2016
Publisher
Taylor & Francis Ltd.
e-ISSN
23312009
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1080/23312009.2016.1235459
ProQuest document ID
1862753562
Copyright
© 2016 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.