Erratum: SC83288 is a clinical development candidate for the treatment of severe malaria

DOI: 10.1038/ncomms15273 OPEN

Erratum: SC83288 is a clinical development candidate for the treatment of severe malaria

Stefano Pegoraro, Malle Duffey, Thomas D. Otto, Yulin Wang, Roman Rsemann, Roland Baumgartner, Stefanie K. Fehler, Leonardo Lucantoni, Vicky M. Avery, Alicia Moreno-Sabater, Dominique Mazier, Henri J. Vial, Stefan Strobl, Cecilia P. Sanchez & Michael Lanzer

Nature Communications 8:14193 doi: http://dx.doi.org/10.1038/ncomms14193

Web End =10.1038/ncomms14193 (2017); Published 31 Jan 2017; Updated 6 Apr 2017

This Article contains errors in Figs 1 and 8 that were introduced during the production process. The compound on the lower right side of Fig. 1 is labelled incorrectly and should be labelled SC83288. The correct version of Fig. 1 appears below as Fig. 1. In Fig. 8c, SC83458 selected should read SC81458 selected and in Fig. 8d SC81758 should read SC81458. The correct version of Fig. 8 appears below as Fig. 2.

NH2

NH

H

N

H

N

O

HN

IC50 10 nM

MM 296 g mol1

Amicarbalide

IC50 10 nM

MM 502 g mol1

NH2

NH2

H

N

H

N

HN

O

S

O

N

O

SC09064

H

O

S

O

NH2

H

N

H

N

H

N

H

N

O

S

O

S

O

O

N

N

O

H

O

H

HN N

N

HN N

N

CH3 O

O

S

NH2

O

NH2

CH3 O

O

S

O

IC50 8 nM

MM 628 g mol1

SC81458

IC50 3 nM

MM 630 g mol1

SC83288

Figure 1

NATURE COMMUNICATIONS | 8:15273 | DOI: 10.1038/ncomms15273 | http://www.nature.com/naturecommunications

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ERRATUM NATURE COMMUNICATIONS | DOI: 10.1038/ncomms15273

a

d

1,800

SC81458 IC 50(nM)

SC81458 IC 50(nM)

1,500 1,200

900

Clone 1i

600 300

2,500

2,000

1,500

1,000

0 0 20 40 60 80 100

0

Clones 13/18

Clones 15/21

PF3D7_0716000 PF3D7_1112700 PF3D7_1317200 PF3D7_0212100 PF3D7_1038400 PF3D7_0529800 PF3D7_1106800 PF3D7_1245200 PF3D7_1465700 PF3D7_0929300 PF3D7_0719900

PF3D7_1466900 PF3D7_1401000 PF3D7_1474600 PF3D7_1221000

PF3D7_1308400 PF3D7_0515600

Clone 4

Clone 15

Clone 1

Clone 9

0

20 40 60 80 100 120

Replicative cycles

b

SC83288 IC 50(nM)

PF3D7_1447900

(PfMDR2)

PF3D7_1241800

(RNA-helicase)

PF3D7_0106300

(PfATP6)

PFATP6 locus

amplification

1237 1237 1237 1237

500 Clone 4

Replicative cycles

SC81458 selected

c

1599 1599

322 322

3x 3x 3x

2x

1599 1608

1599 1608

1599 1608

1599 1608

104

103

102

101

100

SC83288 selected

322325 2915 2915 2915

Clone 21

Clone 18

Clone 13

Clone 1

Clone 9

Clone 1i

100

101

102

103

104

SC83288 IC50 (nM)

SC83288 SC81458

Figure 2

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Web End =http://creativecommons.org/licenses/by/4.0/ r The Author(s) 2017

2 NATURE COMMUNICATIONS | 8:15273 | DOI: 10.1038/ncomms15273 | http://www.nature.com/naturecommunications

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