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About the Authors:
Parnali Dhar-Chowdhury
Affiliations Zoonotic Diseases and Special Pathogens, Public Health Agency of Canada, National Microbiology Laboratory, Winnipeg, Manitoba, Canada, Natural Resources Institute, University of Manitoba, Winnipeg, Manitoba, Canada
Kishor Kumar Paul
Affiliation: Emerging Infections, International Centre for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh
C. Emdad Haque
* E-mail: [email protected]
Affiliation: Natural Resources Institute, University of Manitoba, Winnipeg, Manitoba, Canada
ORCID http://orcid.org/0000-0001-8008-2496
Shakhawat Hossain
Affiliation: Department of Mathematics and Statistics, University of Winnipeg, Winnipeg, Manitoba, Canada
L. Robbin Lindsay
Affiliation: Zoonotic Diseases and Special Pathogens, Public Health Agency of Canada, National Microbiology Laboratory, Winnipeg, Manitoba, Canada
Antonia Dibernardo
Affiliation: Zoonotic Diseases and Special Pathogens, Public Health Agency of Canada, National Microbiology Laboratory, Winnipeg, Manitoba, Canada
W. Abdullah Brooks
Affiliation: Center for Global Health, Johns Hopkins University, Baltimore, Maryland, United States of America
Michael A. Drebot
Affiliation: Zoonotic Diseases and Special Pathogens, Public Health Agency of Canada, National Microbiology Laboratory, Winnipeg, Manitoba, CanadaAbstract
Background
Dengue virus (DENV) activity has been reported in Dhaka, Bangladesh since the early 1960s with the greatest burden of dengue fever and dengue hemorrhagic fever cases observed in 2000. Since this time, the intensity of dengue activity has varied from year to year, and its determining factors remained relatively unknown. In light of such gaps in knowledge, the main objectives of this study were to determine the magnitude of seroprevalence and seroconversion among the surveyed population, and establish the individual/household level risk factors for the presence of DENV antibodies among all age groups of target populations in the city of Dhaka.
Methodology/Principal findings
Considering the lack of fine scale investigations on the factors driving dengue activity in Bangladesh, a prospective cohort study involving serological surveys was undertaken with participant interviews and blood donation across the city of Dhaka in 2012. Study participants were recruited from 12 of 90 wards and blood samples were collected during both the pre-monsoon (n = 1125) and post-monsoon (n = 600) seasons of 2012. The findings revealed that the seroprevalence in all pre-monsoon samples was 80.0% (900/1125) while the seropositivity in the pre-monsoon samples that had paired post-monsoon samples was 83.3% (503/600). Of the 97 paired samples that were negative at the pre-monsoon time point, 56 were positive at the post-monsoon time point. This resulted...