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About the Authors:
Gwanghun Kim
Affiliations Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
Na-Young Ha
Affiliations Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
Chan-Ki Min
Affiliations Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
Hong-Il Kim
Affiliations Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
Nguyen Thi Hai Yen
Affiliations Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
Keun-Hwa Lee
Affiliation: Department of Microbiology and Immunology, Jeju National University School of Medicine, Jeju, Republic of Korea
Inbo Oh
Affiliation: Environmental Health Center, University of Ulsan College of Medicine, Ulsan, Republic of Korea
Jae-Seung Kang
Affiliation: Department of Microbiology, Inha University School of Medicine, Incheon, Republic of Korea
Myung-Sik Choi
Affiliation: Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea
Ik-Sang Kim
Affiliation: Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea
Nam-Hyuk Cho
* E-mail: [email protected]
Affiliations Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea, Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul, Republic of KoreaAbstract
Background
Scrub typhus is a mite-borne febrile disease caused by O. tsutsugamushi infection. Recently, emergence of scrub typhus has attracted considerable attention in several endemic countries in Asia and the western Pacific. In addition, the antigenic diversity of the intracellular pathogen has been a serious obstacle for developing effective diagnostics and vaccine.
Methodology/Principal findings
To understand the evolutionary pathway of genotypic diversification of O. tsutsugamushi and the environmental factors associated with the epidemiological...