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Copyright Nature Publishing Group Apr 2017

Abstract

The exact nature and dynamics of pancreatic ductal adenocarcinoma (PDAC) immune composition remains largely unknown. Desmoplasia is suggested to polarize PDAC immunity. Therefore, a comprehensive evaluation of the composition and distribution of desmoplastic elements and T-cell infiltration is necessary to delineate their roles. Here we develop a novel computational imaging technology for the simultaneous evaluation of eight distinct markers, allowing for spatial analysis of distinct populations within the same section. We report a heterogeneous population of infiltrating T lymphocytes. Spatial distribution of cytotoxic T cells in proximity to cancer cells correlates with increased overall patient survival. Collagen-I and αSMA+ fibroblasts do not correlate with paucity in T-cell accumulation, suggesting that PDAC desmoplasia may not be a simple physical barrier. Further exploration of this technology may improve our understanding of how specific stromal composition could impact T-cell activity, with potential impact on the optimization of immune-modulatory therapies.

Details

Title
Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer
Author
Carstens, Julienne L; Correa De Sampaio, Pedro; Yang, Dalu; Barua, Souptik; Wang, Huamin; Rao, Arvind; Allison, James P; Lebleu, Valerie S; Kalluri, Raghu
Pages
15095
Publication year
2017
Publication date
Apr 2017
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1892273738
Copyright
Copyright Nature Publishing Group Apr 2017