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About the Authors:
Tian Ge
* E-mail: [email protected] (TG); [email protected] (JWS)
Affiliations Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital / Harvard Medical School, Charlestown, MA, United States of America, Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States of America, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, United States of America
Chia-Yen Chen
Affiliations Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States of America, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, United States of America, Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States of America
ORCID http://orcid.org/0000-0001-9548-5597
Benjamin M. Neale
Affiliations Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States of America, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, United States of America, Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States of America
Mert R. Sabuncu
Contributed equally to this work with: Mert R. Sabuncu, Jordan W. Smoller
Affiliations Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital / Harvard Medical School, Charlestown, MA, United States of America, School of Electrical and Computer Engineering and Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, United States of America
ORCID http://orcid.org/0000-0002-7068-719X
Jordan W. Smoller
Contributed equally to this work with: Mert R. Sabuncu, Jordan W. Smoller
* E-mail: [email protected] (TG); [email protected] (JWS)
Affiliations Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States of America, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, United States of America
ORCID http://orcid.org/0000-0002-0381-6334Abstract
Heritability estimation provides important information about the relative contribution of genetic and environmental factors to phenotypic variation, and provides an upper bound for the utility of genetic risk prediction models. Recent technological and statistical advances have enabled the estimation of additive heritability attributable to common genetic variants (SNP heritability) across a broad phenotypic spectrum. Here, we present a computationally and memory efficient heritability estimation method that can handle large sample sizes, and report the SNP heritability...