Salivary levels of interleukin-8 in oral lichen planus and diabetic patients: A biochemical study

Abstract

Received: March 2016 Accepted: January 2017 ABSTRACT Background: This study aimed to assess the salivary levels of interleukin-8 (IL-8) in oral lichen planus (OLP) and diabetes mellitus (DM) patients, and OLP + DM patients in comparison with healthy individuals. The salivary levels of IL-8 and fasting blood sugar and 2-h postprandial blood glucose levels were measured in all the subjects. Key Words: Diabetes mellitus, interleukin-8, lichen planus, saliva INTRODUCTION The etiology of oral lichen planus (OLP) has yet to be clearly understood; however, there is a strong theory that T-cell-mediated immune responses are involved in its pathogenesis. [10] At high glucose levels, IL-8 is produced following the adhesion of monocytes to endothelial cells in diabetic patients. [...]a vicious circle is created within which IL-8 and increased glucose levels mutually affect each other. Based on previous studies, IL-8 has a potential role in OLP and DM. [...]this study aimed to measure the salivary level of IL-8 in 4 groups of OLP, DM, OLP, and DM and healthy controls. Healthy controls were selected from subjects presenting to the laboratories for regular checkups, who had no history of drug intake or systemic diseases. Atefi N, Majedi M, Peyghambari S, Ghourchian S. Prevalence of diabetes mellitus and impaired fasting blood glucose in patients with Lichen Planus. Comparison of the frequency of diabetes mellitus in the patients with lichen planus and normal controls: A case-control study.