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About the Authors:
Jianhua Zhao
Contributed equally to this work with: Jianhua Zhao, Ksenia Beyrakhova
Current address: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
Affiliations The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
ORCID http://orcid.org/0000-0002-4997-766X
Ksenia Beyrakhova
Contributed equally to this work with: Jianhua Zhao, Ksenia Beyrakhova
Affiliation: Department of Biochemistry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Yao Liu
Affiliation: Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America
ORCID http://orcid.org/0000-0002-4330-2389
Claudia P. Alvarez
Affiliations Department of Chemistry, University of Toronto, Toronto, Ontario, Canada, Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada
Stephanie A. Bueler
Affiliation: The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
Li Xu
Current address: Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, United States of America
Affiliation: Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America
ORCID http://orcid.org/0000-0002-6220-9382
Caishuang Xu
Affiliation: Department of Biochemistry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Michal T. Boniecki
Affiliation: Department of Biochemistry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Voula Kanelis
Affiliations Department of Chemistry, University of Toronto, Toronto, Ontario, Canada, Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada, Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
Zhao-Qing Luo
Affiliation: Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America
ORCID http://orcid.org/0000-0001-8890-6621
Miroslaw Cygler
* E-mail: [email protected] (JLR); [email protected] (MC)
Affiliation: Department of Biochemistry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
ORCID http://orcid.org/0000-0003-4579-1881
John L. Rubinstein
* E-mail: [email protected] (JLR); [email protected] (MC)
Affiliations The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, CanadaAbstract
Intracellular pathogenic bacteria evade the immune response by replicating within host cells. Legionella pneumophila, the causative agent of Legionnaires’ Disease, makes use of numerous effector proteins to construct a niche supportive of its replication within phagocytic cells. The L. pneumophila effector SidK was identified in a screen for proteins that reduce the activity of the proton pumping...