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Abstract

To the Editor: Acne inversa (AI; OMIM: 142690) is a painful chronic follicular disease, characterized by recurrent draining sinuses and abscesses with subsequent scarring and chronic seepage, predominantly in skin folds that carry terminal hairs and apocrine glands. The patient reported that cysts appeared repeatedly on his head in August 2002, subsequently, inflammatory subcutaneous nodules developed on the face, neck, and armpit [Figure 1] (the patient with AI refused to provide the photo on his face and neck, now we offer only typical photo in his armpit). The causative genes of some monogenic disorders, such as disseminated superficial actinic porokeratosis,[5] have been found by linkage analysis combined with whole exome sequencing, but we did not find the mutation of these disease-causing genes in some families or sporadic patients, indicating that there may be other causative genes. [...]additional and as yet unknown genes predispose to the development of this distressing disorder....

Details

Title
A Case Report of Inversa Acne and Evaluation for Mutations in the NCSTN, PSENEN, and PSEN1 Genes
Author
Guo, Bi-Rong; Li, Cong-Sheng; Zhu, Qi-Ming; Xu, Kang; Pan, Wei; Jiang, Peng
Publication year
2016
Publication date
Jul 20, 2016
Publisher
Lippincott Williams & Wilkins Ovid Technologies
ISSN
03666999
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1925232723
Copyright
Copyright Medknow Publications & Media Pvt. Ltd. Jul 20, 2016