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Abstract
[...]less attention was paid on the effect of initial OMG symptoms of disease onset such as ptosis and diplopia concurrence or alone, ptosis on one or both eyes on both MG relapse and OMG second generalization. The diagnosis of MG was based on the combination of clinical features and one of the laboratory criteria including favorable effect of cholinesterase inhibitors, positive results of repetitive nerve stimulation or single fiber electromyography and anti-AChR-Abs highly specific for MG. [4] The study was approved by the hospital ethics committee on clinical research and written informed consent was obtained from all of the patients in this study. Autoimmune thyroid diseases such as Graves' disease and antibody positive thyroid disease were diagnosed on the basis of clinical features, thyroid ultrasonography, and serum thyroxin and related autoantibody levels. Results Clinical features of ocular myasthenia gravis patients with different phenotypes There were 33 female and 26 male OMG patients in this study, with a median age of 46.1 +- 18.5 years (range: 4.0-72.0 years). [1] This discrepancy may be related to the different race and heritage background between the two studies. [...]little attention was paid on the relationship of ptosis, as well as diplopia with OMG relapse and second generalization. [...]Concurrent autoimmune diseases such as Hashimoto's thyroiditis and rheumatoid arthritis were found in muscle-specific kinase (MuSK) antibody positive patients (9.6%) and Graves' disease was found in AChR-Ab positive patients. [...]Th17 cell and MuSK antibody, as well as AChR-Ab might contribute to OMG with the concurrence of other...