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Lucas Fernando Sérgio Gushiken [1] and Carlos Alberto Hussni [2] and Jairo Kenupp Bastos [3] and Ariane Leite Rozza [1] and Fernando Pereira Beserra [1] and Ana Júlia Vieira [1] and Carlos Roberto Padovani [4] and Marivane Lemos [3] and Maurilio Polizello Junior [3] and Jonas Joaquim Mangabeira da Silva [3] and Rafael Henrique Nóbrega [1] and Emanuel Ricardo Monteiro Martinez [1] and Cláudia Helena Pellizzon [1]

Academic Editor: Solomon Habtemariam

1, Department of Morphology, Institute of Biosciences of Botucatu, UNESP, Campus Botucatu, Botucatu, SP, Brazil, unesp.br

2, Department of Surgery and Veterinary Anesthesiology, School of Veterinary Medicine and Animal Science, UNESP, Campus Botucatu, Botucatu, SP, Brazil, usp.br

3, Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Campus Ribeirão Preto, Ribeirão Preto, SP, Brazil, usp.br

4, Department of Biostatistics, Institute of Biosciences of Botucatu, UNESP, Campus Botucatu, Botucatu, SP, Brazil, unesp.br

Received Apr 20, 2017; Revised Jun 25, 2017; Accepted Jul 4, 2017

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

1. Introduction

The Copaifera langsdorffii Desf. Kuntze (Leguminosae), popularly known as copaiba, is a native tree from tropical regions of Latin America and Western Africa, which grows in the North, Northeast,and Central-West of Brazil, especially in the States of Amazonas, Paiva et al. [1]. Since the XVI century, the oleoresin of Copaifera langsdorffii has been used by Brazilian Indians to treat some diseases [2] and the popular knowledge reports the use of the plant as anti-inflammatory and antimicrobial agent and to treat skin wounds [1, 3]. Among the biological properties of copaiba, some have already been studied such as anti-inflammatory agent [4], antinociceptive [5], antioxidant [6], gastrointestinal diseases [6–9], pulmonary and urinary disorders [10], urolithiasis [11], and analgesic agent [1, 12]. Furthermore, there are some works [1, 13–17] which studied the wound healing potential of Copaifera langsdorffii through macroscopic analysis and collagen synthesis mechanisms, but there is the necessity of more researches about the wound healing mechanisms of the plant. Most of the studies from Copaifera genus used the oleoresin, with few studies using the aerial parts [18]. However, the aromatic and phenolic compounds...

                                                   

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