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© 2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Objective

This study evaluates the effect of food intake on 92 neurological biomarkers in plasma. Moreover, it investigated if any of the biomarkers were correlated with body mass index.

Materials and Methods

Twenty‐two healthy subjects (11 male and 11 female aged 25.9 ± 4.2 years) were investigated. A total of 92 biomarkers were measured before a standardized meal as well as 30 and 120 min afterward with the Proseek Multiplex Neurology I kit.

Results

The levels for 13 biomarkers decreased significantly (p < .001) 30 min after food intake. The levels for four biomarkers remained significantly decreased (p < .001) 120 min after food intake. One biomarker increased significantly (p < .001) 30 min after food intake. The changes were between 1% and 12%, with an average difference of about 5%. Only one biomarker showed a difference over 10% due to food intake. The biggest difference was observed for Plexin‐B3 120 min after food intake (12%). Of all the 92 neurological biomarkers, only one was correlated with BMI, Kynureninase r = .46, p < .05.

Conclusions

This study shows that food intake has a very modest effect on 92 different neurological biomarkers. Timing of blood sampling in relation to food intake, therefore, appears not to be a major concern. Only Kynureninase was correlated with BMI. Further studies are warranted in older healthy subjects and in patients with various neurological diseases to determine whether the findings are reproducible in such populations.

Details

Title
Effect of food intake on 92 neurological biomarkers in plasma
Author
Dencker, Magnus 1   VIAFID ORCID Logo  ; Björgell, Ola 1 ; Hlebowicz, Joanna 2 

 Department of Medical Imaging and Physiology, Skåne University Hospital, Lund University, Malmö, Sweden 
 Department of Clinical Sciences, Division of Medicine, Skåne University Hospital, Lund University, Malmö, Sweden 
Section
ORIGINAL RESEARCH
Publication year
2017
Publication date
Sep 2017
Publisher
John Wiley & Sons, Inc.
e-ISSN
21623279
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1940867651
Copyright
© 2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.