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Won Seok Lee [1] and Kyung Suk Lee [2] and Shinhae Lee [2] and Myongsoon Sung [3] and Seung-Jin Lee [2] and Hye Mi Jee [2] and Youn Ho Sheen [4] and Man Yong Han [2] and Young-Ho Jung [2]

Academic Editor: Marzia Caproni

1, Department of Pediatrics, Graduate School, Kyung Hee University, Seoul, Republic of Korea, khu.ac.kr

2, Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea, cha.ac.kr

3, Department of Pediatrics, Haeundae Paik Hospital, Inje University School of Medicine, Busan, Republic of Korea, inje.ac.kr

4, Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Republic of Korea, cha.ac.kr

Received Apr 18, 2017; Accepted Aug 13, 2017

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

1. Introduction

Atopic dermatitis (AD) typically arises at an early age and is the most common chronic, relapsing, inflammatory eczematous skin disease [1]. The pathogenesis of AD is complex with multifactorial etiologies involving genetic, immunological, and environmental factors. The prevalence of AD has risen globally in recent years [1]. There are several reasons for this trend, including genetic factors and increasing prevalence of food allergy (FA) [2, 3]. Recently, environmental factors involving air pollution have been considered as a newly emerging cause for the increased prevalence of AD [2].

Indoor air pollution is an important environmental factor for children, as they tend to spend most of their daytime indoors [4]. Materials affecting outdoor air include particulate matter < 10 mm (PM10), nitrogen oxides (NOx), sulfur oxides (SOx), and ozone (O3) [5]. Materials with substantial effect on indoor air pollution are different from outdoor materials [4]. The causative materials of indoor air pollution include wallpaper, flooring, and paint [6]. Formaldehyde, volatile organic compounds (VOCs), and aromatic compounds are pollutants that are considered more important than other indoor chemicals [7]. Mendell reported that indoor pollutants may play a key role in the development and aggravation of allergic diseases such as AD [4]. High concentrations of VOCs or formaldehyde are associated with the development of Sick Building Syndrome (SBS) and the aggravation...
 
 
 
 
   
   
   
   
   

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