Abstract
Possibly, in triggered psoriasis (as in antimalarials), the drug only sets off with a chain of pathologic events previously programmed and ready to be set off; whereas in true drug-induced cases (as in some cases induced by lithium and beta blockers), the drug is supposed to cause more profound changes and therefore more time is needed for these changes to occur. [...] it has been shown that pharmacologic doses of lovastatin do not worsen the course of psoriasis; and though gemfibrozil, an anti-triglyceride agent, has been reported to exacerbate psoriasis, statins have not been reported to do so; and even the lovastatin manufacturer (Merck Sharp and Dome, Rahway, NJ, USA) has anecdotal evidence that the condition of some psoriatic subjects improves when this drug is administered.
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