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Abstract
New specific treatment strategies are demanded as well as experimental models relevant for human sepsis. * Systemic inhibition of two innate immune recognition systems was tested as a therapeutic strategy in a clinically relevant porcine model of sepsis. * Combined inhibition of the complement component C5 and the TLR coreceptor CD14 abrogated complement activation, attenuated physiological derangements, reduced cytokine release and improved survival in a porcine model of polymicrobial sepsis. * This broad-acting “upstream” inhibition of innate immunity might be a therapeutic approach to human sepsis, where inhibition of “downstream” single inflammatory mediators has failed. Tumor necrosis factor Declarations Acknowledgements This work was supported by The Northern Norway Regional Health Authority, The Odd Fellow Foundation, The Simon Fougner Hartmann Family Fund, and the European Community's Seventh Framework Programme under grant agreement number 602699 (DIREKT). L146-54.Google Scholar Borg T, Gerdin B, Modig J. Prophylactic and delayed treatment with indomethacin in a porcine model of early adult respiratory distress syndrome induced by endotoxaemia.