Abstract

Sentieon DNAseq Software is a suite of tools for running DNA sequencing secondary analyses. The Sentieon DNAseq Software produces identical results to the Genome Analysis Toolkit (GATK) Best Practice Workflow using HaplotypeCaller, with more than a 20-fold increase in processing speed on the same hardware.

This paper presents a benchmark analysis of the GATK and Sentieon DNAseq software packages using publically available datasets from the 1000 genomes database, and includes speed comparisons and output concordance analyses.

Details

Title
Sentieon DNA pipeline for variant detection - Software-only solution, over 20× faster than GATK 3.3 with identical results
Author
Weber, Jessica A; Aldana, Rafael; Gallagher, Brendan D; Edwards, Jeremy S
Publication year
2016
Publication date
Jan 22, 2016
Publisher
PeerJ, Inc.
e-ISSN
21679843
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.7287/peerj.preprints.1672v2
ProQuest document ID
1952570654
Copyright
© 2016 Weber et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ PrePrints) and either DOI or URL of the article must be cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.