Abstract

Dysthyroid optic neuropathy (DON) is the commonest cause of blindness in thyroid associated orbitopathy (TAO). While diagnosis remains clinical, objective tests for eyes with early or equivocal findings are lacking. Various electrophysiological studies (EPS) have been reported, yet the types and parameters useful for DON remain inconclusive. We performed a systematic literature search in MEDLINE, EMBASE and the Cochrane databases via the OVID platform up to August 20, 2017. 437 records were identified for screening and 16 original studies (1327 eyes, 787 patients) were eligible for review. Pattern visual evoked potential (pVEP) was the most frequently studied EPS. Eyes of TAO patients with DON showed delayed P100 latencies, decreased P100 amplitudes or delayed N75 latencies during pVEP, compared to those without or healthy controls. Due to study heterogeneity, no quantitative analysis was possible. This review highlights the most common type (pVEP) and useful parameters (P100 latency and amplitude) of EPS, and supports further research on them using standardized testing conditions.

Details

Title
Electrophysiological Studies in Thyroid Associated Orbitopathy: A Systematic Review
Author
Tiara W U Iao 1 ; Shi Song Rong 2   VIAFID ORCID Logo  ; An Ni Ling 1 ; Brelén, Mårten E 3 ; Young, Alvin Lerrmann 3 ; Chong, Kelvin K L 3   VIAFID ORCID Logo 

1  Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China 
2  Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China; Harvard Medical School, and Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA 
3  Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China; Department of Ophthalmology and Visual Sciences, The Prince of Wales Hospital, Hong Kong, China 
Pages
1-10
Publication year
2017
Publication date
Sep 2017
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-017-11998-0
ProQuest document ID
1955044974
Copyright
© 2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.